PE-22-28 Peptide
PE-22-28 PeptidePE-22-28 is a synthetic variant of the naturally occurring peptide Spadin. Spadin is a secreted peptide obtained from Sortilin. It appears to act as an antagonist of the TREK-1 (TWIK-related-potassium channel) receptor, a two-pore potassium channel identified as a potential target in the context of depression research and as a possible neurogenic regulator. Studies in mice have suggested that TREK-1 receptor deletion may make them resistant to depressive behavior and corresponding chemical imbalances in the brain.[1] PE-22-28 represents a shorter seven amino acid synthetic Spadin analog with potentially higher efficacy and stability. Research in animal models is ongoing.
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