Bronchogen

Bronchogen, also known as AEDL, is classified among the Khavinson peptides and is has been suggested by researchers to act as a bioregulator. These are short signaling peptides which may cross through cellular and nuclear membranes to directly interact with the DNA. Bronchogen may have specific affinity for lung cells by regulating the expression of the NKX2-1, SCGB1A1, SCGB3A2, FOXA1, and FOXA2 genes.⁽¹⁾ Furthermore, authors comment that it may “bind preferentially with deoxyribooligonucleotides containing CNG sequence (CNG sites are targets for cytosine DNA methylation in eukaryotes).”⁽²⁾ Indeed, the peptide has been suggested to potentially attenuate inflammatory reactions in the lungs of murine models with bleomycin-induced fibrosis⁽³⁾